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The effects of mismatch fracture properties in encapsulation-based self-healing concrete using cohesive-zone

Luthfi Muhammad MAULUDIN, Chahmi OUCIF, Timon RABCZUK

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 3, Pages 792-801 doi: 10.1007/s11709-020-0629-0

Abstract: Finite element analysis is developed to simulate the breakage of capsule in capsule-based self-healing concrete. A 2D circular capsule with different core-shell thickness ratios embedded in the mortar matrix is analyzed numerically along with their interfacial transition zone. Zero-thickness cohesive elements are pre-inserted into solid elements to represent potential cracks. This study focuses on the effects of mismatch fracture properties, namely fracture strength and energy, between capsule and mortar matrix into the breakage likelihood of the capsule. The extensive simulations of 2D specimens under uniaxial tension were carried out to investigate the key features on the fracture patterns of the capsule and produce the fracture maps as the results. The developed fracture maps of capsules present a simple but valuable tool to assist the experimentalists in designing appropriate capsule materials for self-healing concrete.

Keywords： self-healing concrete interfacial zone capsule materials cohesive elements fracture maps

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Immobilization of

Xiaokai SONG,Zhongyi JIANG,Lin LI,Hong WU

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 3, Pages 353-361 doi: 10.1007/s11705-014-1421-2

Abstract: Mesoporous silica particles were prepared for efficient immobilization of the -glucuronidase (GUS) through a biomimetic mineralization process, in which the solution containing lysozyme and GUS were added into the prehydrolyzed tetraethoxysilane (TEOS) solution. The silica particles were formed in a way of biomineralization under the catalysis of lysozyme and GUS was immobilized into the silica particles simultaneously during the precipitation process. The average diameter of the silica particles is about 200 nm with a pore size of about 4 nm. All the enzyme molecules are tightly entrapped inside the biosilica nanoparticles without any leaching even under a high ionic strength condition. The immobilized GUS exhibits significantly higher thermal and pH stability as well as the storage and recycling stability compared with GUS in free form. No loss in the enzyme activity of the immobilized GUS was found after 30-day’s storage, and the initial activity could be well retained after 12 repeated cycles.

Keywords： and recycling stability silica nanoparticles biocatalysis biomimetic synthesis β-glucuronidase encapsulation

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Encapsulation of polyethylene glycol in cellulose-based porous capsules for latent heat storage and light-to-thermal

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 8, Pages 1038-1050 doi: 10.1007/s11705-022-2279-3

Abstract: Phase change materials are potential candidates for the application of latent heat storage. Herein, we fabricated porous capsules as shape-stable materials from cellulose-based polyelectrolyte complex, which were first prepared using cellulose 6-(N-pyridinium)hexanoyl ester as the cationic polyelectrolyte and carboxymethyl cellulose as the anionic polyelectrolyte to encapsulate polyethylene glycol by the vacuum impregnation method. Furthermore, the multi-walled carbon nanotube or graphene oxide, which were separately composited into the polyelectrolytes complex capsules to enhance thermal conductivity and light-to-thermal conversion efficiency. These capsules owned a typical core–shell structure, with an extremely high polyethylene glycol loading up to 34.33 g∙g^‒1. After loading of polyethylene glycol, the resulted cellulose-based composite phase change materials exhibited high thermal energy storage ability with the latent heat up to 142.2 J∙g^‒1, which was 98.5% of pure polyethylene glycol. Further results showed that the composite phase change materials demonstrated good form-stable property and thermal stability. Moreover, studies involving light-to-thermal conversion determined that composite phase change materials exhibited outstanding light-to-thermal conversion performance. Considering their exceptional comprehensive features, innovative composite phase change materials generated from cellulose presented a highly interesting choice for thermal management and renewable thermal energy storage.

Keywords： cellulose polyelectrolytes phase change materials thermal energy storage light-to-thermal conversion

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The Architecture of a Product Collaborative Design Platform Based on Cloud Manufacturing

Wei Wei, Wang Yufei, Tao Yong

Strategic Study of CAE 2020, Volume 22, Issue 4, Pages 34-41 doi: 10.15302/J-SSCAE-2020.04.014

Abstract:

Product design is crucial to improving product quality and lowering manufacturing costs. Cloud manufacturing is emerging as a new manufacturing model and an integrated technology and has become an important development direction for advanced manufacturing. To adapt to the transformation of traditional manufacturing to service-oriented and innovative manufacturing, this study investigates the current status of collaborative design and summarizes the problems regarding the sharing and on-demand use of massive resources in traditional manufacturing. It also proposes the architecture of a product collaborative design platform based on cloud manufacturing and explains the meaning of each layer in detail. Then three key technologies for building the platform are discussed: cloud manufacturing technology, product family and product platform technology, and product collaborative design technology. Finally, using a cloud-manufacturing-based product collaborative design platform system established by a company as an example, the system architecture and functions of the platform are analyzed, and the differences in task assign and completion time between cloud manufacturing and traditional manufacturing are compared. The effectiveness and superiority of the cloud manufacturing-based system are verified, and the application and research direction of the system are prospected.

Keywords： cloud manufacturing collaborative design product platform resource encapsulation platform architecture

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Enzyme@bismuth-ellagic acid: a versatile platform for enzyme immobilization with enhanced acid-base stability

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 6, Pages 784-794 doi: 10.1007/s11705-022-2278-4

Abstract: In situ encapsulation is an effective way to synthesize enzyme@metal–organic framework biocatalystsAfter encapsulation, the stability, especially the acid-base stability, of amyloglucosidases@bismuth-ellagicgreen precursor, simple and convenient preparation process provided a versatile strategy for enzymes encapsulation

Keywords： bismuth-ellagic acid in situ encapsulation enzyme@MOF biocomposites

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Studies on preparation of folate-targeted boron liposomes as potential delivery agents for neutron capture therap

Wang Zhihui,Qin Linxue,Liu Dong

Strategic Study of CAE 2012, Volume 14, Issue 8, Pages 78-81

Abstract:

To prepare folate-targeted liposomes with high encapsulation efficiencyThe content and the encapsulation efficiency of HBA,TBA or BBA liposomes are evaluated by high performanceAs the basis of the encapsulation efficiency, the optimal conditions for preparing liposomes were exploredThe encapsulation efficiency of HBA, TBA and BBA liposomes were 25.7 %, 38.9 % and 94.8 % at the optimal

Keywords： boron neutron capture therapy liposomes folate-targeted encapsulation efficiency

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Microfluidics for cell-cell interactions: A review

Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1, Pages 90-98 doi: 10.1007/s11705-015-1550-2

Abstract: The well-designed microscale intermediary is also ideal for the study of cell biology.Particularly, microfluidic chip is helpful for better understanding cell-cell interactions.

Keywords： microfluidic chip co-culture cell-cell interactions review

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Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Frontiers of Medicine Pages 939-956 doi: 10.1007/s11684-023-0987-9

Abstract: 645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 mice by single-cellMNDCMs having interactions with macrophages and non-proliferative MNDCMs (non-pMNDCMs) with minimal cell–cellThese MNDCMs were mapped to the heart by integrating the spatial and single-cell transcriptomic data.In conclusion, a novel non-pMNDCM subpopulation with minimal cell–cell communications was unveiled, highlighting

Keywords： mononuclear diploid cardiomyocytes cell–cell communication cardiac fibroblast single-cell RNA sequencing

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Deubiquitinases as pivotal regulators of T cell functions

Xiao-Dong Yang, Shao-Cong Sun

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 451-462 doi: 10.1007/s11684-018-0651-y

Abstract: Defect in T cell activation is associated with severe immune deficiencies, whereas aberrant T cell activationAn emerging mechanism that regulates T cell activation and tolerance is ubiquitination, a reversibleIt is now well recognized that DUBs are crucial regulators of T cell responses and serve as potential

Keywords： deubiquitinase ubiquitination T cell activation T cell differentiation T cell tolerance

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Cell surface protein engineering for high-performance whole-cell catalysts

Hajime Nakatani,Katsutoshi Hori

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1, Pages 46-57 doi: 10.1007/s11705-017-1609-3

Abstract: Cell surface protein engineering facilitated by accumulation of information on genome and protein structureinvolves heterologous production and modification of cell surface proteins using genetic engineering, and is important for the development of high-performance whole-cell catalysts.In this field, cell surface display is a major technology by exposing target proteins, such as enzymes, on the cell surface using a carrier protein.

Keywords： cell surface engineering surface display whole-cell catalysts bioprocess

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Stem cell niches and endogenous electric fields in tissue repair

Li LI, Jianxin JIANG

Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 40-44 doi: 10.1007/s11684-011-0108-z

Abstract: Endogenous adult stem cells reside in certain regions of organs, known as the stem cell niche, whichMany regulatory factors are involved in the stem cell-based repair process, including stem cell nichesHere we briefly review the role of stem cell niches and endogenous electric fields in tissue repair,and hypothesize that endogenous electric fields become part of stem cell niche in the wound site.

Keywords： stem cell stem cell niche electric field tissue repair

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CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies

Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 783-804 doi: 10.1007/s11684-021-0904-z

Abstract: Chimeric antigen receptor T-cell (CAR T) immunotherapy opens a new path for targeted therapy of hematologicalIn this review, through a representative case study, we summarize the current experience of CAR T-cellthe causative mechanisms of therapy resistance, and new strategies to improve the efficacy of CAR T-cell

Keywords： CAR T cells hematological malignancies review

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Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 503-517 doi: 10.1007/s11684-022-0947-9

Abstract: Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCCALDOB inhibited CtBP2-mediated repression of multiple cell cycle inhibitor, proapoptotic, and epithelial

Keywords： ALDOB kidney cancer cell proliferation

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The unregulated commercialization of stem cell treatments: a global perspective

Douglas Sipp

Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 348-355 doi: 10.1007/s11684-011-0150-x

Abstract: notwithstanding, hundreds of companies and private clinics around the world now sell putative stem cellIn this review, I provide an overview of the global industry in pseudomedical stem cell treatments, with

Keywords： stem cell tourism medical ethics stem cell policy and regulation alternative medicine

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Fine-tuning cell organelle dynamics during mitosis by small GTPases

Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 339-357 doi: 10.1007/s11684-022-0926-1

Abstract: coordination of genetic material inheritance with organelle dynamics directs accurate mitotic progression, cellSmall GTPases belonging to the Ras superfamily regulate various cell organelles during division.the key regulators of membrane dynamics, the dysregulation of small GTPases is widely associated with cellThis review collects current knowledge on small GTPases in the regulation of cell organelles during mitosisand highlights the mediator role of small GTPase in transducing cell cycle signaling to organelle dynamics

Keywords： small GTPase cell organelle mitosis